acquired drug-resistance

Resistance phenomena , especially acquired drug-resistance , have been severely hampering the applications of chemotherapeutics during chemotherapy of tumor .

在肿瘤化疗的过程中，耐药现象的存在，尤其是获得性耐药，严重阻碍了化疗药物的应用。

However , their low water solubility , acquired drug-resistance , myelosuppression and severe gastrointestinal disturbances promoted people to search for new derivatives of podophyllotoxin .

然而，这类化合物还存在水溶性低、获得性耐药、骨髓抑制和严重的胃肠道反应等缺点，促使人们寻找新的鬼臼毒素衍生物。

Methods Clinic isolates of Mycobacterium tuberculosis from 1996 to 2004 in Shanghai were analyzed and the proportion of isolates from new cases ( the proxy of primary drug-resistance ) and retreatment cases ( the proxy of acquired drug-resistance ) were calculated .

方法对上海市疾病预防控制中心收集保存的1996年至2004年结核分枝杆菌临床菌株进行分析统计，计算原发性耐药和获得性耐药的比例；

Methotrexate ( MTX ) is a first-line and essential component in combined chemotherapy in the treatment of choriocarcinoma . However acquired drug-resistance is common and serious in choriocarcinoma . It is estimated that about 30 % of patients will develop drug-resistance if single MTX is used .

甲氨蝶呤（Methotrexate，MTX）是治疗绒癌的首选药物，也是在绝大多数联合化疗方案中必需的药物，但MTX获得性耐药严重，单一MTX约30%患者将出现耐药。